Police were called to Loampit Vale, near the junction with Station Road, to reports of a collision between a pedestrian and cyclist shortly before 10.50pm.
A woman believed to be in her 40s was treated at the scene by paramedics and taken to the hospital as a priority.
Her injuries are not believed to be life-threatening.
Police have not made an arrest at this stage, as enquiries continue.
A London Ambulance Service spokesperson said: “We were called at 10.47pm yesterday (16 July) to reports of a collision involving a bus and a pedestrian outside Lewisham station.
“We sent an ambulance crew, a medic in a car, an incident response officer, and an advanced paramedic.
“A woman was treated at the scene and taken to a hospital as a priority.”